Description
Product Characteristics: FUNCTION: Adapter protein that links SCN10A to clathrin. Regulates SCN10A channel activity, possibly by promoting channel internalization. SUBCELLULAR LOCATION: Cytoplasm. Note: Cell periphery. TISSUE SPECIFICITY: Detected in small neurons in dorsal root ganglia. Detected in C-type fibers of sciatic nerve.,Ion Channel Interacting,Sodium channel and clathrin linker 1, Sodium channel-associated protein 1, SAP1
Target Information: SCLT1 acts as a linker protein between the voltage-gated sodium channel Na(v)1.8 (SCN10A\, MIM 604427) and clathrin (see CLTC, MIM 118955) (Liu et al., 2005 [PubMed 15797711]).[supplied by OMIM, Mar 2008]